RU 486.

Mifepristone (RU 486) in Cushing's syndrome.

CONTEXT Mifepristone (RU 486) blocks the action of cortisol by binding to the glucocorticoid receptor and, therefore, is of potential therapeutic value in Cushing's syndrome. However, research in endogenous hypercortisolism has been hampered by the controversy related to the use of mifepristone for inducing abortion. Currently, new studies are planned to better define the role of RU 486 in Cush...

RU 486: the politics of choice.

Reversal of multidrug resistance by RU 486.

P-Glycoproteins represent a family of drug efflux proteins that convey multidrug resistance to cells in which they are expressed. This phenomenon can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug efflux. We report that the antiprogestin RU 486 can reverse multidrug resistance in cells overexpressing the m...

Mifepristone (ru-486) and Its Analogues

Mifepristone (RU-486) is the first antiprogesterone drug used for the termination of early pregnancies (6 to 8 weeks pregnancies), a steroid synthesized in the laboratory. It has higher affinity for the progesterone receptor. It also has other potential applications as anticancer and glucocorticoid antagonist. It is desirable to increase its antiprogestational potency and eliminate the antigluc...

Approval of RU-486 as a Postcoital Contraceptive

Each year in the United States, 3.5 million women unintentionally become pregnant.3 Moreover, approximately 1.5 million abortions are performed annually,4 making the United States' abortion rate one of the highest among Western countries.' Meanwhile, the number of women and children living below the poverty level continues to increase. 6 These facts indicate that women urgently need additional ...